Technologieangebote

This humanized monoclonal antibody efficiently neutralizes HSV fully in-dependent of complement or immune effector cell recruitment and completely abrogates viral cell-to-cell spread, a key mechanism by which HSV escapes humoral immune surveillance.

The invention provides a cell based high-throughput screening system for agents that influence DNA methylation by determining the methylation status of an internal promoter.

The aim of radiation therapy is to eradicate a tumor without causing significant damage to contiguous normal tissue. For precise field shaping of the radiation beam multileaf collimators (MLC) have been broadly established. The linear servo MLC presented here provides various advantages over conventionally employed MLCs like reduced size and weight, dynamic leaf movements up to 4 m/s, direct fixation of the linear servo rod to the associated leaf and position sensors are implemented in the linear drives.

Modifications of histones are known to play a role in cancer altering accessibility of DNA for transcriptional processes. So detection methods for enzymes modifying histones are of urgent need. We established two hybridoma cell lines producing antibodies directed against HDAC11suitable for immunocytochemistry, chromatin IP, and Western Blot.

70-80% of newly diagnosed breast tumors account for hormone receptor positive breast cancer (also known as luminal breast cancer). The histologic grade of luminal breast cancer is often determined by semi-quantitative methods describing morphologic features related to the differentiation states of the tumor specimen. In order to make a clear-cut classification of luminal breast cancer as either “grade 1” (= low risk) or “grade 3” (= high risk) tumors, DKFZ researchers have developed a 3-protein marker set.

By using Hall effect sensors and electromagnetic induction coils, the magnetic flux density, the change in magnetic flux density, and the change in magnetic flux can be monitored simultaneously. The compact measuring sensor is connected to the supply and data storage device via a signal cable and can be attached to any body part. A fully functional prototype has already been constructed and tested.