Technologieangebote

Bei Untersuchungen von Blut- und Gewebeproben von Hepatitis C-Patienten wurden verschiedene potentielle Biomarker gefunden, die sich nicht nur zur frühen und…

Die Erfindung beschreibt neue spezifische Oligopeptide aus TAA, die sich besonders gut als Zielstrukturen für die Therapie und das Immunmonitoring von…

Scientists at the Georg-August-University generated different monoclonal antibodies which specifically react with either Il-8RA (CXCR1, Cdw128A) or Il-8RB (CXCR2, Cdw128B), a G protein linked seven transmembrane domain protein, expressed on monocytes, granulocytes and on a subset of T cells. Interleukin-8 (IL-8) is a potent inflammatory mediator that belongs to the family of C-X-C chemokines. IL-8 promotes the activation and the extravasation of circulating neutrophils to the site of inflammation. Two IL-8 receptor isotypes (type A and B) are identified in human and rabbit neutrophils. Both receptor subtypes A and B bind with high affinity to human IL-8, but they exhibit distinct binding affinity to two functional and structurally related IL-8 peptides, melanoma growth-stimulating activity peptide (MGSA) and neutrophil-activating peptide-2 (NAP-2). Human IL-8 receptor A binds with low affinity to MGSA or NAP-2. In contrast, human IL-8 receptor B binds MGSA with high affinity, and NAP-2 with lesser affinity.

Scientists at the Georg-August-University produced different monoclonal antibodies directed against beta-arrestin1 and beta-arrestin2 (one reacts specifically with beta-arrestin1 but not beta-arrestin2, the other one with both of them). Arrestins are cytosolic proteins that are involved in G protein-coupled receptor (GPCR) desensitization. Arrestin binding to activated GPCRs phosphorylation dependent and once bound, uncouple the GPCR from the associated heterotrimeric G proteins. There are currently known 4 mammalian isoforms, beta-arrestin1 (arrestin2), beta-arrestin2 (Arrestin3), visual arrestin (Arrestin1), and cone arrestin. The beta-isoforms are ubiquitously expressed and known to interact with acetylcholine and adrenergic receptors.

Am Institut für Verfahrenstechnik der RWTH Aachen wurde ein Membrankontaktormodul (MKM Modul) speziell für Stoff- und Energieaustauschprozesse im Gegenstrom…

Studenten des Instituts für Schiffstechnik und Transportsysteme IST der Universität Duisburg-Essen haben sich die Aufgabe gestellt, gleichzeitig…