Technologieangebote

Die neue Technologie betrifft eine Elektrode zum konduktiven Erwärmen von Formplatinen von Fahrzeugteilen, insbesondere von rechteckigen Bauteilen (z.B. Bumper, Crashbox, Seitenaufprallträger). Die Technologie bietet weiterhin folgenden Nutzen: Verringerung des Verschnitts und
Steigerung der Energieeffizienz.

The invention concerns an actuator system which allows up to 100% availability. lt comprises a number of redundant actuator sub-units working completely independent which can be replaced during system Operation without reducing system functionality.

An algorithm has been developed to determine the distance between an RFID-Reader and a tag involved in the communication. The algorithm can be applied
for existing tags without the need for modification and can be used for passive, semi-passive, and active tags.

High-grade textiles (e.g. Cashmere, Pashmina and other natural fibers) are nowadays often counterfeited. Cashmeres shawls labeled as „100% Pashmina” can be made out of almost 100% polyester or other synthetic fibers. For this reason, a tool to proof the fabric composition declared on the label is very desirable. The object of this invention is a reliable method to determine the type and the nature of a fiber. The characteristic diffraction pattern of the fiber, recorded with an USB camera, enables the determination of the thickness, the surface structure as well as the grade of transparency and eventually the internal structure of the fiber. On the base of this information a reliable identification of the fiber material is provided.

Cancer-immunotherapy is currently gaining interest thanks to novel genetic engineering technologies. The most promising approach is the chimeric antigen receptor (CAR) technique for redirecting hereby modified T cells against cancer-associated antigens. The herein presented CAR constitutes of a B cell-derived single chain antibody fragment (scFv) directed against TOSO. This ectodomain is fused with a co-stimulatory CD28 T cell activation domain, finally followed by a CD3ζ domain. The receptor is introduced into allogenic or autologous peripheral blood T cells by retroviral gene transfer.

Cell-based assays show high killing specificity of the anti-TOSO CAR T cells against CLL cells, whereas normal B cells remain intact. The discrimination is strongly improved in comparison to previously engineered anti-CD19 CAR T cells that are currently used in clinical studies.

The described anti-TOSO CAR T cells have a strongly improved selectivity of target cell killing. The reduction of adverse effects on normal cells provides a competitive advantage against all other CAR T cell approaches that are currently on the market.

On behalf of the University of Cologne, PROvendis offers a patent license as well as a research collaboration with licensing option.

The recombinant peroxidase-protein G fusion protein is recombinantely produced at high yields in bioreactor cultivations of Pichia pastoris. The used process enables reproducible products of consistent high quality due to independence of varying enzyme isolates and chemical conjugation procedures.