Cytokinin Receptor Antagonists and Compositions Containing these Derivatives

<strong>Background</strong><br>

Cytokinins are plant hormones involved in cell division, shoot meristem and leaf formation, chloroplast biogenesis, and senescence. The development of agonists and antagonists with a particular physiological effect is useful in mechanism-of-action studies of biologically active natural products. The potent naturally occurring cytokinin N6-isopentenyladenine served as the basis for initial structure-activity studies.</p> <p><!–break–><strong>Technology</strong><br> We offer substituted 6-(alkylbenzylamino)-purin derivatives as cytokinin receptor antagonists to provide cytokinin analogons for growth regulation in plants and to offer the possibility for a specific selectivity for cytokinin receptors without being toxic for animal cells. The derivatives can be used to influence morphology, leading to:</p> <ul> <li>Increased root growth, fruit or grain size</li> <li>Stimulation of root branching and enhanced number of lateral roots</li> <li>Accelerated seed germination</li> <li>Enhanced yield and quality of crops</li> </ul> <br> <b>Benefits:</b><br><ul> <li>Non toxic for animal cells</li> <li>Efficiency is proven in various test systems</li> <li>Suitable regulator for proliferation and morphogenesis in tissue culture</li> </ul><br> </strong><strong>IP Rights</strong><br> Czech Patent Application was filed in 2007<br> PCT Patent Application was filed in 2008<br> National applications filed in USA and Europe</p> <p><strong>Patent Owner</strong><br> <ul> <li>Freie Universität Berlin</li> <li>Palacky University Olomouc (CZ)</li> </ul>

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